Abstract
Repeated determinations of the antistreptolysin content of the serum in normal individuals and in patients suffering from a variety of chronic diseases unrelated to streptococcus infections showed that in the majority of cases the titer fell 25-50 units, and rarely more than 100 units. Only slight variations were observed in the titers of the serum from healthy individuals followed over periods as long as a year. In acute infections, other than hemolytic streptococci, titers above 100 units were encountered a little more frequently and occurred in 22.7% of 66 cases. In only 2 of the 66 cases were the titers elevated to 200 units or above.