The Complete Primary Structure of Protein Kinase C—the Major Phorbol Ester Receptor
- 22 August 1986
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 233 (4766) , 853-859
- https://doi.org/10.1126/science.3755547
Abstract
Protein kinase C, the major phorbol ester receptor, was purified from bovine brain and through the use of oligonucleotide probes based on partial amino acid sequence, complementary DNA clones were derived from bovine brain complementary DNA libraries. Thus, the complete amino acid sequence of bovine protein kinase C was determined, revealing a domain structure. At the amino terminal is a cysteine-rich domain with an internal duplication; a putative calcium-binding domain follows, and there is at the carboxyl terminal a domain that shows substantial homology, but not identity, to sequences of other protein kinase.Keywords
This publication has 39 references indexed in Scilit:
- The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1Cell, 1985
- Further characterization of tumor-promoter-mediated activation of protein kinase CBiochemical and Biophysical Research Communications, 1984
- Activation of protein kinase C by non-phorbol tumor promoter, mezereinBiochemical and Biophysical Research Communications, 1984
- Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cellsNature, 1984
- Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphateNature, 1983
- Amino acid sequence of the catalytic subunit of bovine type II adenosine cyclic 3',5'-phosphate-dependent protein kinaseBiochemistry, 1983
- Simian Sarcoma Virus onc Gene, v- sis , Is Derived from the Gene (or Genes) Encoding a Platelet-Derived Growth FactorScience, 1983
- Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virusNature, 1983
- Phospholipid turnover as a possible transmembrane signal for protein phosphorylation during human platelet activation by thrombinBiochemical and Biophysical Research Communications, 1980
- Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene productNature, 1980