Effects of aging on the in vitro response of human lymphocytes to interleukin-2.

1 January 1984

journal article
research article
Published by Japanese Society of Internal Medicine in Japanese Journal of Medicine

Vol. 23 (3) , 211-215
https://doi.org/10.2169/internalmedicine1962.23.211

Abstract

Effects of aging on the in vitro responses of human peripheral blood lymphocytes (PBL) to interleukin-2 (IL-2, T cell growth factor) were studied. Aged PBL showed a significantly lower response to phytohemagglutinin (PHA) than young PBL. Proliferative responses to exogenous IL-2 showed by aged PBL were the same as those of young PBL. Cultured lymphoid cells propagated in IL-2 (CLC-IL-2) derived from both young and aged PBL showed a strong cytotoxic reactivity against the natural killer (NK) sensitive target K562.