EFFECT OF LARGE DOSES OF RADIOIODINE ON THYROID FUNCTION

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Abstract
The effect was studied of large doses of radioiodine on the relative amounts of various organic iodine compounds present in the thyroid glands of rats. At 24 hours there was no effect of radiation from I131 on the relative amounts of diiodotyrosine, monoiodotyrosine, and thyroxine plus triiodothyronine found in the gland. After 48 hours and 5 days, during which time there is known to be considerable destruction of epithelial cells, there was an inhibition of thyroxine synthesis but not of the iodination of tyrosine. There is evidence that even at some days after irradiation at the levels used some follicles are preserved and able to synthesize hormones.

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