Intrauterine Pneumonia

Abstract
Several agents usually supposed from experiments done on adult animals and during extrauterine life to induce a ‘congenital pneumonia’, have been directly introduced into the amniotic cavity of rabbit fetuses and their effects studied after 72 hours. Human meconium, rabbit amniotic cellular debris, gastric juice or acidified amniotic fluid did not produce any granulocytic inflammatory reaction within the lungs or the fetal membranes. The injection of various types of bacteria revealed on microscopic examination an acute chorioamnionitis and usually also the peculiarities (intrapulmonary polymorphs and amniotic fluid cells; no fibrin; no septicemia) of an ‘intrauterine pneumonia’, resembling the congenital pneumonia’ of the human infant. The umbilical cord and other fetal mucous membranes disclosed no inflammatory lesions. These experiments argue in favour of an exclusive bacterial origin in the induction of an intrauterine pneumonia.

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