Antibiotika aus Basidiomyceten, XV [1]. 1-Hydroxy-2-nonin-4-on, ein antifungischer und cytotoxischer Metabolit aus Ischnoderma benzoinum (Wahl.) Karst. / Antibiotics from Basidiomycetes. XV [1]. 1-Hydroxy-2-nonyn-4-one, an Antifungal and Cytotoxic Metabolite from Ischnoderma benzoinum (Wahl.) Karst.
Open Access
- 1 February 1982
- journal article
- Published by Walter de Gruyter GmbH in Zeitschrift für Naturforschung C
- Vol. 37 (1-2) , 1-4
- https://doi.org/10.1515/znc-1982-1-201
Abstract
A new antibiotic, 1 -hydroxy-2-nonyn-4-one (1), has been isolated from submerged cultures of several strains of Ischnoderma benzoinum. The compound exhibits high inhibitory activity against yeasts and filamentous fungi at concentrations of 1-5 μg/ml. DNA, RNA, and protein syntheses in cells of the ascitic form of Ehrlich carcinoma are strongly inhibited by the same concentrations.Keywords
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