Danazol and Migraine

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Abstract
To the Editor: The article by Ahn et al. on the use of danazol and Gelfand's accompanying editorial (June 9 issue) 1 , 2 prompted our interest in employing this drug for the treatment of migraine. Migraine may be regarded as an endocrine-associated disorder, since approximately 60 per cent of women with this disorder have attacks at the time of their menstrual period.3 These attacks are normally preceded by fluid retention, which is not always relieved by diuretics.4 Although the relation between water retention and sex-hormone change is not understood, it is well documented.3 Danazol has been shown to suppress the enzymatic synthesis . . .

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