Statin Use and Leg Functioning in Patients With and Without Lower-Extremity Peripheral Arterial Disease
- 11 February 2003
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Circulation
- Vol. 107 (5) , 757-761
- https://doi.org/10.1161/01.cir.0000050380.64025.07
Abstract
Background— We determined whether statin use (versus nonuse) is associated with superior lower-extremity functioning independently of cholesterol levels and other confounders in patients with and without peripheral arterial disease. Methods and Results— Participants included 392 men and women with an ankle brachial index (ABI) P =0.045), faster walking velocity (0.93 versus 0.89 m/s, P =0.006), and a higher summary performance score (10.2 versus 9.4, P Conclusions— Statin use is associated with superior leg functioning compared with no statin use, independent of cholesterol levels and other potential confounders. These data suggest that non–cholesterol-lowering properties of statins may favorably influence functioning in persons with and without peripheral arterial disease.Keywords
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