Decreased anterior cingulate gyrus metabolic rate in schizophrenia
- 1 May 1997
- journal article
- research article
- Published by American Psychiatric Association Publishing in American Journal of Psychiatry
- Vol. 154 (5) , 682-684
- https://doi.org/10.1176/ajp.154.5.682
Abstract
OBJECTIVE: This study examined glucose metabolism in the anterior and posterior cingulate cortex in schizophrenia. METHOD: Fifty unmedicated male schizophrenic patients and 24 normal men were studied with positron emission tomography. RESULTS: Compared with the normal men, the schizophrenic patients had lower relative metabolic rates in the anterior cingulate and higher rates in the posterior cingulate. CONCLUSIONS: The findings suggest hypofunction in the anterior cingulate cortex in schizophrenia.Keywords
This publication has 12 references indexed in Scilit:
- Charting the circuitsNature, 1995
- Decreased DOPAC in the anterior cingulate cortex of individuals with schizophreniaBiological Psychiatry, 1995
- Contributions of anterior cingulate cortex to behaviourBrain, 1995
- Reduced [3H]flunitrazepam binding in cingulate cortex and hippocampus of postmortem schizophrenic brains: Is selective loss of glutamatergic neurons associated with major psychoses?Neurochemical Research, 1993
- Posterior Cingulate Cortex and Visuospatial Cognition: Properties of Single Neurons in the Behaving MonkeyPublished by Springer Nature ,1993
- Neurobiological Investigations in Cingulate Cortex of Schizophrenic BrainSchizophrenia Bulletin, 1993
- Hypofrontality in Neuroleptic-Naive Patients and in Patients With Chronic SchizophreniaArchives of General Psychiatry, 1992
- Limbic System Abnormalities Identified in Schizophrenia Using Positron Emission Tomography With Fluorodeoxyglucose and Neocortical Alterations With Deficit SyndromeArchives of General Psychiatry, 1992
- Prediction of social skill acquisition in schizophrenic and major affective disorder patients from memory and symptomatologyPsychiatry Research, 1991
- Localization of a human system for sustained attention by positron emission tomographyNature, 1991