The effect of tri-iodothyronine administration on protein synthesis in the diabetic rat

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Abstract
In young male rats diabetes caused decreases in circulating free triiodothyronine and RNA concentration in liver and muscle, and in the rate of protein synthesis per unit of RNA (RNA activity) in muscle. Triiodothyronine treatment significantly increased RNA concentrations, but not RNA activity, in these tissues. Impaired thyroid status is a component of the diabetic condition; triiodothyronine cannot stimulate the translational phase of protein synthesis in the diabetic rat.