Inhibition of Carcinogenic and Toxic Effects of Polycyclic Hydrocarbons by Several Sulfur-Containing Compounds2
- 1 May 1974
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 52 (5) , 1583-1587
- https://doi.org/10.1093/jnci/52.5.1583
Abstract
Disulfiram, dimethyldithiocarbamate, and benzyl thiocyanate, when added to the diet, inhibited 7,12- dimethylbenz[a]anthracene (DMBA)-induced mammary tumor formation and adrenal necrosis in female SpragueDawley rats. A single oral administration of disulfiram given 24 hours before the carcinogen similarly inhibited DMBA-induced mammary tumor formation. In the mouse, disulfiram prevented the occurrence of tumors of the forestomach that resulted from benzo[a]pyrene in the diet but did not affect pulmonary adenoma formation in mice given this carcinogen by oral intubation.Keywords
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