Abstract
The curious geographic variations in the prevalence of Paget's disease remain unexplained and the viral hypothesis remains unproved. An association between transient hyperphosphataemia of infancy and subsequent Paget's disease has not been established. Some 5% of Pagetic patients have hyperparathyroidism although the mechanism of this apparent association remains unknown. Several agents are available for the medical treatment of Paget's disease but there is a lack of consensus concerning therapeutic aims.