FAILURE OF HYPOTHALAMIC LESIONS TO PREVENT THYROID STIMULATION BY OESTROGEN IN THE RAT

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Abstract
Oestrogens probably influence thyroid function through several mechanisms (Brown-Grant, 1960; Ślebodziński, 1962; Plunkett, Squires & Heagy, 1963) and whether the effect is stimulant or depressant depends on dosage, duration of treatment and probably on species. Two types of hypothalamic lesions have been described which interfere with TSH release in the rat. Relatively small lesions in the anterior hypothalamus and the suprachiasmatic region are claimed to block the release of TSH with enhanced demand, e.g. during exposure to cold (D'Angelo, 1960) or administration of goitrogens (Bogdanove & Halmi, 1953). The importance of this area for TSH release has been questioned (e.g. van Beugen & van der Werff ten Bosch, 1960). However, there is general agreement that more posterior lesions of the median eminence block TSH release under all conditions (Harris, 1960), although this effect may be due to pituitary infarction. The effect of electrolytic lesions in these two positions on 131

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