Mirex induces ornithine decarboxylase in female rat liver

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Abstract
Ornithine decarboxylase, the rate-limiting enzyme in polyamine synthesis, was significantly induced in female rat liver following oral administration of the pesticide mirex. After dual oral exposure (120 mg /kg of mirex; 21 and 4 hr prior to sacrifice), ornithine decarboxylae activity in rat liver cytosol was 70-fold higher than control values. A single oral dose of mirex (180 mg /kg) induced hepatic ornithine decarboxylase activity 55-fold over controls. After a single oral dose of mirex the maximal induction of ODC activity occurred at 36 hr. Mirex is an unusually potent and long-lasting inducer of rat hepatic ornithine decarboxylase activity.

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