Immunohistochemical Localization of Type D Retrovirus Serotype 1 in the Digestive Tract of Rhesus Monkeys With Simian AIDS

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Abstract
Type D retrovirus infection of rhesus macaques (Macaca mulatta) shares many features with AIDS in man including gastrointestinal signs such as chronic diarrhea and wasting. In some humans and macaques afflicted with these signs and symptoms no etiology can be established. In this study immunohistochemistry was employed to localize D/l/California in the digestive tract of ten animals with simian AIDS. This revealed that both epithelial and lymphoid cells of the digestive tract are commonly infected by this immunosuppressive type D retrovirus.
Funding Information
  • U.S. Public Health Service