The leucocyte migration inhibition test and subpopulations of peripheral lymphocytes in insulin-dependent diabetics.

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Abstract
The leukocyte migration inhibition test (LMT) was performed by the agarose plate method with thyroid and pancreatic antigens [Ag] in patients with insulin-dependent or -independent diabetes mellitus. The mean migration indices with thyroglobulin, thyroid mitochondria and beef insulin were not significantly different in insulin-dependent diabetics from those in insulin-independent diabetics or normal controls. Significant inhibition of leukocyte migration was observed in insulin-dependent diabetics when thyroid microsome or pancreatic extract was used as Ag. Although no significant difference was found in the percentages of T [thymus-derived] and B [bone marrow-derived] lymphocytes between insulin-dependent diabetics and insulin-independent diabetics or normal controls, LMT results strongly suggest the presence of cellular immunity against the thyroid and pancreas in insulin-dependent juvenile-onset diabetes.