Psoralen Photosensitization of L 1210 Leukaemia Cells: an Approach to a New Combined Therapy
Open Access
- 1 February 1978
- journal article
- research article
- Published by Walter de Gruyter GmbH in Zeitschrift für Naturforschung C
- Vol. 33 (1-2) , 92-95
- https://doi.org/10.1515/znc-1978-1-217
Abstract
Psoralen photosensitization of L1210 mouse leukemia cells has a strong effect on DNA and RNA syntheses and this result appears connected with the psoralen photobinding to DNA. Protein synthesis is less sensitive and its inhibition seems due to a different photochemical interaction, likely to psoralen photobinding to RNA. Combined therapy using cyclophosphamide and psoralen-photoinactivated L1210 cells was performed after leukemia transplant, showing a significant decrease in mortality, even in comparison with simple treatment with the alkylating drug.Keywords
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