Events Leading to Major Amputation in Patients with Arteriosclerosis

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Abstract
THE treatment of arteriosclerosis of the legs has changed considerably in the past several years, notably through the introduction of antibiotics and anticoagulants and through the recognition of the value of sympathectomy. These advances have been accompanied by a substantial reduction in the incidence of major amputation. A further reduction in the loss of extremities might follow a clearer recognition of the causes of gangrene or of causes not formerly appreciated. Added benefit should result from scrutiny of treatment of the arteriosclerotic patient, and especially of methods of handling a necrosis that is still localized.To obtain information bearing on . . .

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