Precursors of mitochondrial proteins are degraded in the cytosol at different rates
- 15 December 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 209 (2) , 227-230
- https://doi.org/10.1016/0014-5793(86)81116-4
Abstract
The stability of rat liver mitochondrial protein precursors in the cytosol was investigated. The precursors were synthesized in a post-mitochondrial supernatant from rat liver, and mitochondria were then added at different times. The amount and pattern of proteins incorporated were determined. The precursors have different rates of transport into mitochondria. Some precursors are stable in the cytosol while most are degraded rapidly, with a half-life of about 30 min at 30°C.Keywords
This publication has 9 references indexed in Scilit:
- Adenosine 5'‐triphosphate stimulates the release of polypeptides from mitochondriaFEBS Letters, 1985
- The effects of insulin and glucose on the induction and intracellular translocation of δ-aminolevulinic acid synthaseArchives of Biochemistry and Biophysics, 1984
- Transport and Regulation of Polypeptide Precursors of Mature Mitochondrial ProteinsCurrent Topics in Cellular Regulation, 1984
- Transport of Proteins into MitochondriaPublished by Elsevier ,1984
- Hemin inhibits transfer of pre-δ-aminolevulinate synthase into chick embryo liver mitochondriaBiochemical and Biophysical Research Communications, 1983
- Biogenesis of mitochondrial proteins. Regulation of production of δ-aminolaevulinate synthase by haemin in embryonic-chick liverBiochemical Journal, 1983
- Exit of proteins and fragments thereof from mitochondria is accelerated by the import of cytosolic synthesized proteinsBiochemical and Biophysical Research Communications, 1983
- Synthesis, intracellular transport, and processing of the precursors for mitochondrial ornithine transcarbamylase and carbamoyl-phosphate synthetase I in isolated hepatocytes.Proceedings of the National Academy of Sciences, 1981
- A Film Detection Method for Tritium‐Labelled Proteins and Nucleic Acids in Polyacrylamide GelsEuropean Journal of Biochemistry, 1974