Comparison of rotavirus strains by hemagglutination inhibition

Publisher Website
Google Scholar
Abstract
Rotaviruses are of importance as etiologic agents of gastroenteritis in infants and in domestic animals of several species. Hemagglutinins were prepared from 2 Canadian isolates of bovine rotavirus and from 1 isolate of a simian rotavirus. A United Kingdom isolate of bovine rotavirus did not possess hemagglutinating activity, indicating a strain difference between a Canadian and a United Kingdom bovine rotavirus. In hemagglutination-inhibition (HAI) tests a rabbit hyperimmune (2 injections) serum, prepared to 1 of the bovine rotaviruses, was not helpful in distinguishing the 2 bovine viruses because of cross-reactions between the viruses. It was possible to distinguish the bovine viruses from the simian virus with this serum. When guinea pig immune sera were prepared to the 4 rotavirus strains and tested with the 3 hemagglutinins in the HAI test, antigenic differences between the 4 strains of rotavirus were demonstrated. Hyperimmune guinea pig serum prepared to a strain of human rotavirus did not inhibit any of the 3 hemagglutinins, indicating that the human strain is different from the 3 rotavirus strains which gave hemagglutinins.

This publication has 0 references indexed in Scilit: