Transforming growth factor‐β induced by live or ultraviolet‐inactivated equid herpes virus type‐1 mediates immunosuppression in the horse
Open Access
- 1 April 1997
- journal article
- research article
- Published by Wiley in Immunology
- Vol. 90 (4) , 586-591
- https://doi.org/10.1046/j.1365-2567.1997.00202.x
Abstract
Up to 21 days after exposure to live or ultraviolet-inactivated equid herpesvirus type-1 (EHV-1) autologous serum from ponies caused an immunosuppressive effect if incorporated into T-cell proliferation assays to EHV-1. The suppressive factor in the sera of ponies also inhibited T-cell response to phytohaemagglutinin. Increased levels of circulating activated transforming growth factor-β1 (TGF-β1) were detected, and the suppressive activity of the serum could be reversed by antibody to TGF-β1. In a challenge experiment the ponies which exhibited circulating TGF-β1 activity succumbed to infection while the ones with similar magnitudes of T-cell responses, but no TGF-β1 activity, were protected. A definition of this immunosuppressive mechanism and its mode of induction must be central to the design of vaccines and to an understanding of the pathogenesis of EHV-1.Keywords
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