Morphology of lipid alterations in the epidermis: A review
- 1 May 1997
- journal article
- review article
- Published by Wiley in Microscopy Research and Technique
- Vol. 37 (3) , 180-192
- https://doi.org/10.1002/(sici)1097-0029(19970501)37:3<180::aid-jemt3>3.0.co;2-s
Abstract
An overview of the morphological correlates of mammalian epidermal lipids and the cutaneous permeability barrier is provided. The following features are discussed: 1) ultrastructural characterization of the progressive lipid alterations accompanying normal stratum corneum (SC) formation; 2) effects of drugs/inhibitors that interfere with specific aspects of epidermal lipid metabolism; 3) lipid alterations in certain human skin disorders; 4) effects of selected topical emollients on SC lipid organization; and 5) potential pitfalls in interpretation of ultrastructural data in terms of cutaneous function and dysfunction. Microsc. Res. Tech., 37:180–192, 1997.Keywords
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