The Incidence of Posttransfusion Serum Hepatitis

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Abstract
A survey was made to determine the incidence of serum hepatitis following transfusions of blood and plasma over a 4-yr. period, beginning Dec., 1943. Questionnaires were sent to 1300 control patients and 1523 patients who had been transfused with blood or plasma. Satisfactory responses were obtained from 1000 controls and 936 transfused patients. Among the 1000 controls there were 2 patients (0.2 %) with "probable hepatitis." Among the 936 transfused patients there were 20 (2.2%) with "possible hepatitis" and 12 (1.3%) with "probable hepatitis." There were 382 patients who received blood only, and only one (0.3%) had "probable hepatitis"; in the group of 528 who received plasma with or without blood there were 12 (2.1%) cases. These patients received a total of 3723 transfusions of blood or plasma which represents an incidence of one case of "probable hepatitis" per 300 units of transfused blood or plasma. Of the 936 transfused patients, 528 received a total of 2351 units of plasma, with or without whole blood. Ten of these 528 patients had "probable hepatitis," an incidence of one case of hepatitis for every 235 plasma transfusions.
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