Development of a 7,12-Dimethylbenz[a]anthracene-lnduced, Transplantable, Hormone-Sensitive Mammary Tumor in the Rat2

Publisher Website
Google Scholar
Abstract
Two transplantable mammary tumors were developed from initial 7,12-dimethylbenz[a]anthraceneinduced neoplasms; they were characterized histologically and hormonally. Both tumors had good transplantability, with 65–75% of third-generation tumor fragments growing by the end of 21 days. One tumor was characterized histologically as a sarcoma. It was the faster growing of the two and did not respond to ovariectomy, estrogen administration, or anterior pituitary (AP) kidney capsule grafts; also, it did not contain detectable estrogen receptors. The other tumor, characterized as an adenoma, grew more slowly; ovariectomy retarded its growth, estradiol and AP grafts stimulated its growth, and it had a high concentration of estrogen receptors.

This publication has 0 references indexed in Scilit: