Abstract
The diabetogenic action of crude ox ant. lobe extracts was investigated in the following species: mouse, rat, guinea-pig, rabbit, cat and dog. The mouse, rat and guinea-pig are almost completely insensitive to the diabetogenic action of an extract which is effective in other spp. With rabbits and cats, glycosuria and ketonuria followed the daily inj. of a crude extract in 25-50% of the cases investigated, but with dogs, only one failure (in a pregnant bitch) was recorded in 25 expts. In the dog, glycosuria, hyperglycaemia and ketonuria appeared only after 3 or 4 daily injs. of extract, and then disappeared within 4 or 5 days in spite of the continued daily inj. of the same dose of extract. The diabetic symptoms reappeared, however, if the daily dose was suitably increased, and subsided only to be revived by a further increase in the amt. of extract injected daily. If a sufficiently large daily inj. was given the diabetic condition continued indefinitely after cessation of injs. [Young, 1937, 2]. Preparation and conservation of the extract at low temp. was essential for the demonstration of diabetogenic activity. Acetone-desiccation of the fresh gland diminished its diabetogenic activity. With dogs, a non-glycosuric polyuria (up to 300 ml./kg./day) was induced by the daily inj. of ant. lobe extracts of which the diabetogenic factor was inactivated. Such a polyuric action of crude extracts was not observed in mice, rats, guinea-pigs or rabbits. The diabetogenic extracts used in the expts. did not cause any marked rise of blood sugar immediately after inj. The name "diabetogenic factor" (not hormone) should be reserved for the substance (or substances) present in ant. pituitary extracts, which possesses true diabetogenic activity and has little or no action on the blood sugar level within a few hrs. of inj.

This publication has 3 references indexed in Scilit: