Association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity
- 15 April 2005
- journal article
- research article
- Published by Springer Nature in Diabetologia
- Vol. 48 (5) , 900-905
- https://doi.org/10.1007/s00125-005-1723-5
Abstract
Loss of pancreatic beta cells is the crucial event in the development of type 1 diabetes. It is the result of an imbalance between autoimmune destruction and insufficient regeneration of islet cells. To study the role of islet cell regeneration in the pathogenesis of type 1 diabetes, we focused on PAX4, a paired homeodomain transcriptional repressor that is involved in islet cell growth.Keywords
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