Relationship of Baseline Serum Cholesterol Levels in 3 Large Cohorts of Younger Men to Long-term Coronary, Cardiovascular, and All-Cause Mortality and to Longevity

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Abstract
For middle-aged populations, especially men, serum cholesterol consistently has been shown to be a significant risk factor for coronary heart disease (CHD) and the major cardiovascular diseases (CVDs).1-5 The relationship is continuous, graded, strong, independent of other risk factors, predictive, and generally assessed as etiologically significant. This judgment is reinforced by results of many randomized controlled trials in middle-aged and older persons with average, borderline high, and high serum cholesterol levels; these trials demonstrate that effective, sustained reduction of serum cholesterol levels by dietary measures, pharmacologic means, or both reduces CHD and CVD risk.4,5