The reduction of SU-4885 by adrenal glands and other tissues and its inhibition by ACTH
- 1 May 1968
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry
- Vol. 46 (5) , 463-469
- https://doi.org/10.1139/o68-070
Abstract
Rat adrenal glands convert 2-methyl-l,2-bis(3-pyridyl)-l-propanone (SU-4885) [metopirone] in vitro to a product with physical and chemical properties indicating the reduction to 2-methyl-l,2-bis(3-pyridyIJ-1-propanol. The same compound is also formed by the reduction of SU-4485 with NaBH4. The reductionof SU-4885 also occurs in the presence of frog adrenal, rat kidney, and most actively, rat liver tissue, and depends on the concentration of SU-4885 in the incubation medium. Added deoxycorticosterone, at the concentration used, had no effect, but ACTH inhibited the reduction by both adrenal and liver tissue.This publication has 9 references indexed in Scilit:
- The effects of mepyrapone (SU 4885) and some hypercholesterolaemic drugs on hepatic sterol and fatty acid oxidationBiochemical Pharmacology, 1967
- MECHANISM OF METOPIRONE INHIBITION OF A SOLUBLE ADRENAL STEROID 11β-HYDROXYLASECanadian Journal of Biochemistry, 1967
- EFFECT OF ACTH ON METABOLISM OF RADIOACTIVE C-21 STEROIDS BY QUARTERED RAT ADRENALS1967
- INHIBITION OF THE BIOSYNTHESIS OF 18-HYDROXY-11-DEOXYCORTICOSTERONE BY SU-4885Canadian Journal of Biochemistry, 1965
- Effect of adrenalectomy, sham operation or ACTH on the cortisol metabolizing enzymes of rat liver homogenateMetabolism, 1965
- In VitroEffect of 2-Methyl-l,2-bis(3-pyridyl)-l-propanone (Su-4885) and NADPH in the Mouse Adrenal12Endocrinology, 1964
- The excretion of allotetrahydrocortisol in human urineBiochemical Journal, 1957
- IDENTIFICATION OF CORTICOSTEROIDS OF BEEF ADRENAL EXTRACT BY PAPER CHROMATOGRAPHYJournal of Biological Chemistry, 1951
- PAPER CHROMATOGRAPHY OF STEROIDS .2. CORTICOSTEROIDS AND RELATED COMPOUNDS1951