Ro 13-9904 and GR 20263, two new cephalosporins with broad-spectrum activity: an in vitro comparison with other B-actam antibiotics

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Abstract
Ro 13–9904 (Ro) and GR 20263 (GR), two new parenteral cephalosporins, were compared with other β-lactam antibiotics against a total of 237 recent clinical isolates. Both Ro and GR had good activity against the Enterobacteriaceae, with 90% of isolates being inhibited by 025 mg/1 of Ro and by 05 mg/1 of GR. Against Pseudomonas aeruginosa, GR was about four times more active than Ro which, in turn, was at least eight times more active than carbenicillin. Both Ro and GR were highly active against β-lactamase producing and non-β-lactamase producing Haemophilus influenzae. Against the Bacteroides fragilis group, neither Ro nor GR showed good activity, the MIC90 for Ro being 32 mg/1 and the MIC90 for GR being > 128 mg/l. Both Ro and GR were less active than cephalothin against Staphylococcus aureus.

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