Benzodiazepines. X. Oxidation of Tetrahydro-1, 4-benzo-diazepine Derivatives

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Abstract
By UV irradiation in dimethyl sulfoxide (DMSO) or acetone tetrahydro-1,4-benzodiazepines of type 1 and 6-chloro-1-cyclopropylmethyl-4-phenyl-1,2,3,4-tetrahydroquinazolin-2-one were oxidized to the corresponding dihydro compounds. 7-Chloro-1-methyl-5-phenyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one was prepared from 4-acetyl-7-chloro-1-methyl-2,3,4,5-tetrahydro-5-phenyl-1H-1,4-benzodiazepine by oxidation with KMnO4 followed by acid hydrolysis. Oxidation of other types of 4-acylbenzodiazepine derivatives was also examined.

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