CARCINOGENICITY OF HYDROXYLATED ALKYLNITROSOUREAS AND OF NITROSOOXAZOLIDONES BY MOUSE SKIN PAINTING AND BY GAVAGE IN RATS

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  • 1 January 1983
    • journal article
    • research article
    • Vol. 43  (1) , 214-221
Abstract
The carcinogenic effectiveness of a number of nitrosoalkylamides related to nitrosoethylurea and nitroso-n-propylurea was compared by topical application to Swiss mice and by intragastric administration to F344 rats. Nitrosohydroxyethylurea and the related cyclic nitrosamide, nitrosooxazolidone, were as potent as nitrosoethylurea as skin carcinogens, although the latter was a much weaker mutagen to Salmonella. When administered orally nitrosooxazolidone induced mainly forestomach tumors in rats, while nitrosohydroxyethylurea was very broadly acting, inducing neoplasms of the lung, forestomach, glandular, colon, duodenum, and bone (osteogenic sarcomas). Nitroso-2-hydroxypropylurea, nitroso-3-hydroxypropylurea, and nitroso-5-methyloxazolidone were all much more potent carcinogens on mouse skin than was nitro-n-propylurea, nitroso-5-methyloxazolidone being somewhat less effective than the nitrosoureas; the mutagenicity to Salmonella seemed not to be quantitatively related to carcinogenicity. Nitroso-5-methyloxazolidone given orally to rats induced mainly forestomach neoplasms and a few neoplasms of the duodenum, whereas similar treatment of rats with nitroso-2-hydroxypropylurea induced a high incidence of neoplasms of the thymus, some of the forestomach, and few at any other site.

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