SITE OF ACTION OF 5-HYDROXYTRYPTOPHAN AND 5-HYDROXYTRYPTAMINE ON HYPOTHALAMO-PITUITARY-ADRENAL SYSTEM INVITRO

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  • 1 January 1975
    • journal article
    • research article
    • Vol. 46  (3) , 253-256
Abstract
5-Hydroxytryptamine [5-HT] at a concentration of 0.04 .mu.g/ml was able to block the ACTH release caused by hypothalamic tissue (CRF) [corticotropin releasing factor] while it was ineffective when a hypothalamic extract containing CRF was used. 5-Hydroxytryptophan [5-HTP] added to rat adrenal tissue caused a dose-dependent increase in corticosterone production. In a dose of 0.04 .mu.g/ml, 0.4 .mu.g/ml and 4.0 .mu.g/ml, 5-hydroxytryptophan was able to inhibit the ACTH release caused by hypothalamic tissue in vitro. However, 0.04 .mu.g/ml was ineffective on the increase in ACTH secretion elicited by hypothalamic extract CRF. The inhibitory action of 5-HTP and 5-HT may be exerted at the hypothalamic level by inhibiting the release and/or synthesis of the corticotrophic releasing factor.

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