EMBRYONIC NEUROPATHY A HYPOTHESIS OF NEURAL CREST INJURY AS THE PATHOGENESIS OF CONGENITAL MALFORMATIONS
- 1 February 1974
- journal article
- research article
- Published by Wiley in The Medical Journal of Australia
- Vol. 1 (6) , 159-163
- https://doi.org/10.5694/j.1326-5377.1974.tb50781.x
Abstract
Radiological analysis of the limb deformities of thalidomide children reveals evidence of a sensory neuropathic process. Based on this, a hypothesis of neural crest injury is suggested as the underlying pathogenetic mechanism of many congenital malformations. Using a simple concept of four different modes of growth in the embryo, the hypothesis appears to explain both skeletal and visceral deformities. Experimental and pathological evidence is presented in its support, and a rational approach to congenital defect syndromes is suggested.Keywords
This publication has 15 references indexed in Scilit:
- Segmental embryonic peripheral neuropathyPediatric Radiology, 1975
- THALIDOMIDE AND CONGENITAL CHARCOT'S JOINTSThe Lancet, 1973
- Some congenital abnormalities: Possibly due to embryonic peripheral neuropathyClinical Radiology, 1973
- A radioautographic study of the migration and fate of cranial neural crest cells in the chick embryoThe Anatomical Record, 1966
- DEPLETIONS OF PHARYNGEAL ARCH CARTILAGES FOLLOWING EXTIRPATION OF CRANIAL NEURAL CREST IN CHICK EMBRYOSCells Tissues Organs, 1964
- THALIDOMIDE AND CONGENITAL ABNORMALITIESThe Lancet, 1962
- CORTISONE THERAPY IN EARLY PREGNANCY: RELATION TO CLEFT PALATEThe Lancet, 1956
- CONGENITAL INTESTINAL ATRESIA OBSERVATIONS ON ITS ORIGINThe Lancet, 1955
- The Influence of the Nerve in Regeneration of the Amphibian ExtremityThe Quarterly Review of Biology, 1952
- The nervous system and regeneration of the forelimb of adult triturus. II. The role of the sensory supplyJournal of Experimental Zoology, 1943