TSH-Induced Release of 5-Hydroxytryptamine and Histamine from Rat Thyroid Mast Cells
- 1 March 1972
- journal article
- other
- Published by The Endocrine Society in Endocrinology
- Vol. 90 (3) , 795-801
- https://doi.org/10.1210/endo-90-3-795
Abstract
The effect of TSH on rat thyroid mast cells was investigated by a combination of chemical, histochemical, electron microscopical, and bio-assay procedures. In T4-pretreated rats, a single iv injection of TSH reduced the concentration of 5-hydroxytryptamine (5-HT) and histamine in thyroid mast cells, whereas mast cells outside the thyroid seemed unaffected. In rats kept on propylthiouracil and iodine-poor diet for 4 weeks, plasma TSH levels were raised ten-fold. At the same time, follicle cells and mast cells in the thyroid increased in number, but the concentration of S-HT and histamine in individual thyroid mast cells was reduced. Ultrastructurally, there were no overt signs of mast cell degranulation, whether upon short-term or long-term TSH stimulation. It is concluded that, in the rat, TSH induces a release of 5-HT and histamine from intrathyroidal mast cells, which seems to occur without any concomitant degranulation. This release may be involved in the process of thyroid hormone secretion. (Endocrinology90: 795, 1972)Keywords
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