Synthesis and Biological Activity of Various Selenenyl and Tellurenyl-Substituted Deoxyuridines and Deoxyuridylates
- 1 January 1989
- journal article
- abstracts
- Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids
- Vol. 8 (5) , 1135-1140
- https://doi.org/10.1080/07328318908054310
Abstract
5-Methylselenenyl and 5-phenyltellurenyldeoxyuridines were constructed via the transmetallation of the corresponding 5-bromo-3′,5′-bis(dimethyl-tert-butyl)silyl deoxyuridine with n-butyllithium followed by electrophilic trapping of the anion with the appropriate reagent. These substituted deoxyuridylates have been evaluated as potenital inhibitors of Lactobacillus casei thymidylate synthase.Keywords
This publication has 0 references indexed in Scilit: