Vitamin D signalling pathways in cancer: potential for anticancer therapeutics
Top Cited Papers
- 1 September 2007
- journal article
- review article
- Published by Springer Nature in Nature Reviews Cancer
- Vol. 7 (9) , 684-700
- https://doi.org/10.1038/nrc2196
Abstract
Epidemiological studies indicate that vitamin D insufficiency could have an aetiological role in various human cancers. Preclinical research indicates that the active metabolite of vitamin D, 1alpha,25(OH)2D3, also known as calcitriol, or vitamin D analogues might have potential as anticancer agents because their administration has antiproliferative effects, can activate apoptotic pathways and inhibit angiogenesis. In addition, 1alpha,25(OH)2D3 potentiates the anticancer effects of many cytotoxic and antiproliferative anticancer agents. Here, we outline the epidemiological, preclinical and clinical studies that support the development of 1alpha,25(OH)2D3 and vitamin D analogues as preventative and therapeutic anticancer agents.Keywords
This publication has 153 references indexed in Scilit:
- RETRACTED: 1α,25(OH)2D3-induced DNA methylation suppresses the human CYP27B1 geneMolecular and Cellular Endocrinology, 2007
- Histone Methylation-Dependent Mechanisms Impose Ligand Dependency for Gene Activation by Nuclear ReceptorsCell, 2007
- Vitamin D and prevention of colorectal cancerThe Journal of Steroid Biochemistry and Molecular Biology, 2005
- 25-Hydroxy-Vitamin D Metabolism in Human Colon Cancer Cells during Tumor ProgressionBiochemical and Biophysical Research Communications, 2001
- Vitamin D3-induced Apoptosis of Murine Squamous Cell Carcinoma CellsJournal of Biological Chemistry, 2001
- 1α,25-Dihydroxyvitamin D3–Induced Myeloid Cell Differentiation Is Regulated by a Vitamin D Receptor–Phosphatidylinositol 3-Kinase Signaling ComplexThe Journal of Experimental Medicine, 1999
- The Interaction of the Vitamin D Receptor with Nuclear Receptor Corepressors and CoactivatorsBiochemical and Biophysical Research Communications, 1998
- The Promoter of the Human 25-Hydroxyvitamin D31α-Hydroxylase Gene Confers Positive and Negative Responsiveness to PTH, Calcitonin, and 1α,25(OH)2D3Biochemical and Biophysical Research Communications, 1998
- 1,25-Dihydroxyvitamin D3 induces morphological and biochemical markers of apoptosis in MCF-7 breast cancer cellsThe Journal of Steroid Biochemistry and Molecular Biology, 1996
- Differential Modulation of fos and jun Gene Expression by 1,25-Dihydroxyvitamin-D3Biochemical and Biophysical Research Communications, 1993