AY-4166 Increases the Sensitivity of Insulin Secretion to Glucose in Isolated Perfused Rat Pancreas
- 1 February 1998
- journal article
- research article
- Published by Georg Thieme Verlag KG in Hormone and Metabolic Research
- Vol. 30 (02) , 77-79
- https://doi.org/10.1055/s-2007-978839
Abstract
To study the effect of a therapeutic dose (3µM) of AY-4166 on the glucose-stimulated insulin secretion, the rat pancreas was perfused with 5∼15 mM glucose. AY-4166 did not affect the basal insulin secretion at 5 mM glucose, and increased the first and second phases of insulin secretion stimulated by 7.5∼15 mM glucose. The dose-response curve of the insulin secretion to glucose was shifted to the left side by AY-4166. These results suggest that AY-4166 ist not a stimulator releasing insulin independently of glucose concentrations, but a potentiator of insulin secretion.Keywords
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