Activation of Platelets by Platelet Activating Factor (PAF) Derived from IgE-Sensitized Basophils.

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Abstract
Platelet activating factor (PAF) derived from antigen-stimulated, Ig[immunoglobulin]E-sensitized rabbit basophils acts on platelets to induce aggregation and secretion of their content of granule-bound vasoactive amines. Despite this, PAF did not activate platelet factor 3 [PF3]. In contrast, collagen induced aggregation, secretion and PF3 activation in the washed platelets. Other stimuli (ADP, C3b [b fragment of the 3rd complement component] thrombin) also initiated both secretion and PF3 activation. A wide dose range of PAF, including those giving maximal secretion and aggregation, were ineffective in making PF3 available and the possibility that PAF inhibited PF3, or its generation, was also excluded. PAF is apparently a unique stimulus for platelets and secretion and aggregation are not necessarily accompanied by PF3 generation.