Some Physical Chemical Aspects of Receptor-Ligand Interactions

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Abstract
Quantitative evaluations of a variety of immunologically important binding reactions usually assume that the reactants are homogeneously dispersed in solution for purposes of calculation. However, many reactions involve cell-bound receptors which are present at exceedingly high local concentrations on discrete particles. How such a distribution can influence the experimentally measured binding constants is discussed. The additional complexities introduced when multipoint attachment between the ligand and cell-bound receptors is possible and the possible biological implications of this are considered.