INHIBITION OF RNA DEPENDENT DNA-POLYMERASES BY ANTHRACYCLINE ANTIBIOTICS

  • 1 January 1982
    • journal article
    • research article
    • Vol. 29  (1) , 37-42
Abstract
The effects of the anthracycline antibiotics adriamycin, daunomycin and carminomycin on the RNA-dependent DNA polymerase, i.e., reverse transcriptase (RT), system were studied. The rate of selectivity of these antibiotics on the RT was investigated by comparing the above effects to those found on natural nucleic acid polymerases. These experiments were confirmed using synthetic polynucleotid template poly(rA)n(dT)12-18 for the Rauscher RT enzyme and poly(dA)n.cntdot.poly(dT)n for Escherichia coli DNA polymerase I. Carminomycin, in contrast to adriamycin and daunomycin, possesses a highly specific inhibitory effect on the RT enzyme system.

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