BRONCHOPLEURAL FISTULA COMPLICATING INVASIVE PULMONARY ASPERGILLOSIS

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Abstract
Pleural involvement has been notably absent in reviews of invasive pulmonary aspergillosis. Development of a bronchopleural fistula complicating invasive aspergillosis is described in a woman receiving chemotherapy for leukemia. The fungal hydropneumothorax occurred despite early diagnosis of the pulmonary infection and prompt treatment with amphotericin B. Closed pleural drainage and continued antifungal medication resulted in ultimate cure of the infection. The presumed pathophysiologic aspects of this event are discussed and the literature on pleural aspergillosis is reviewed.