Comparative Plasma Levels of Mephenesin and its Carbamic Acid Ester

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Abstract
Mephenesin and its carbamic acid ester were orally administered to 4 normal males; the plasma levels of the respective drugs were determined at various intervals in each subject for 4 hours following administration of the drugs. Significantly higher and more persistent plasma levels were attained by mephenesin carbamate, as compared to those of mephenesin. No free mephenesin was found in the plasma of those subjects receiving mephenesin carbamate.