Preparation and investigation of potentiality of different soft ferrites for hyperthermia applications

Abstract
Water-based ferrofluids of substituted ferrites Fe 1 − x Mn x Fe 2 O 4 ( 0 ⩽ x ⩽ 1 ) have been prepared by the co-precipitation method and characterized. Particles are superparamagnetic with an average particle size of about 10 – 12 nm . The specific absorption rate (SAR) was measured by calorimetric measurement at a frequency of 300 kHz and a field of 10 – 45 kA ∕ m . The variation of SAR and magnetization of Fe 1 − x Mn x Fe 2 O 4 with Mn concentration shows similar dependence. Innocuousness studies of Mn Fe 2 O 4 ferrofluids to the living cells have been carried out with BHK-21 cells.In vitro studies showed that threshold biocompatible concentration is dependent on the nature of ferrites and coating.