The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice
- 1 October 1988
- journal article
- Published by Springer Nature in Nature
- Vol. 335 (6191) , 606-611
- https://doi.org/10.1038/335606a0
Abstract
When the human immunodeficiency virus transactivating gene under the control of the viral regulatory region is introduced into the germline of mice, skin lesions are induced that resemble Kaposi's sarcoma seen in AIDS. Our findings indicate that HIV could play a direct part in causing cancer.Keywords
This publication has 42 references indexed in Scilit:
- Detection of specific sequences among DNA fragments separated by gel electrophoresisPublished by Elsevier ,2006
- The tat Gene of Human T-Lymphotropic Virus Type 1 Induces Mesenchymal Tumors in Transgenic MiceScience, 1987
- A Transgenic Mouse Model for Human NeurofibromatosisScience, 1987
- Trans-activation of human immunodeficiency virus occurs via a bimodal mechanismCell, 1986
- Kaposi's sarcoma in acquired immune deficiency syndrome (AIDS).Journal of Clinical Pathology, 1986
- Long-Term Cultures of HTLV-III—Infected T Cells: a Model of Cytopathology of T-Cell Depletion in AIDSScience, 1986
- The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeatCell, 1985
- Complete nucleotide sequence of the AIDS virus, HTLV-IIINature, 1985
- T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAVNature, 1984
- The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirusNature, 1984