Studies on the activities of tannins and related compounds from medicinal plants and drugs. VII. Effects of extracts of leaves of Artemisia species, and caffeic acid and chlorogenic acid on lipid metabolic injury in rats fed peroxidized oil.

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Abstract
The effects of oral administration of the extracts from the leaves of several Artemisia species, and of chlorogenic acid, which is one of their components, and also of caffeic acid (which can be produced by partial hydrolysis of caffeoylquinic acids, which are the main polyphenolic components in their species) on lipid metabolic injury produced in rats by feeding peroxidized oil were investigated. The acetone-water extracts of the leaves of A. princeps. A. montana and A. capillaris reduced the elevation of lipid peroxide concentration in the serum in peroxidized oil-fed rats, and the above extracts reduced the levels of liver triglyceride. The extracts of A. montana and A. capillaris inhibited the elevation of serum glutamic oxaloacetic transaminase and glutamic pyruvic transaminase. Caffeic acid and chlorogenic acid also inhibited the elevation of serum triglyceride, lipid peroxides, total cholesterol, glutamic oxaloacetic transaminase and glutamic pyruvic transminase, as well as liver lipid peroxide.

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