Acquired Pyruvate Kinase Deficiency with Hemolysis in Preleukemia
- 1 January 1977
- journal article
- research article
- Published by S. Karger AG in Acta Haematologica
- Vol. 57 (6) , 339-343
- https://doi.org/10.1159/000207900
Abstract
Acquired erythrocyte pyruvate kinase deficiency may appear as a symptom secondary to various hematologic disorders, e.g. acute leukemia, sideroblastic anemia, polycythemia vera. The case of a 68-year-old patient with PK deficiency (1.75 U/g Hb) and severe hemolytic anemia is presented, who 1 year later showed acute myeloid leukemia. It is considered that a dialysable inhibiting factor may play a pathogenetic role in this enzyme change since enzyme activity was raised by dialysis. A survey of the literature is presented.Keywords
This publication has 1 reference indexed in Scilit:
- Hereditary Non-spherocytic Hemolytic Anemia of the Pyruvate-kinase Deficient TypeAnnals of Internal Medicine, 1963