Severe haemophilia A in a female resulting from two de novo factor VIII mutations
- 1 August 1995
- journal article
- case report
- Published by Wiley in British Journal of Haematology
- Vol. 90 (4) , 906-909
- https://doi.org/10.1111/j.1365-2141.1995.tb05213.x
Abstract
Summary. A 2‐year‐old girl is described with severe haemophilia A (factor VIII: C de novo in the maternal germ line. Further study of the factor VIII gene inherited by the proband from her father showed the presence of a de novo gene inversion mutation (a type 1, distal pattern inversion). Neither parent showed any evidence of the factor VIII inversion in their somatic DNA. The severe haemophilia A documented in this girl is therefore the result of two de novo mutations affecting the factor VIII gene, a maternally derived X chromosome deletion and a paternal factor VIII inversion mutation.Keywords
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