ADRB2 Polymorphisms and Asthma Susceptibility: Transmission Disequilibrium Test and Meta-Analysis
- 1 June 2004
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 134 (2) , 150-157
- https://doi.org/10.1159/000078648
Abstract
The beta(2)-adrenergic receptor (ADRB2) is the most common adrenergic receptor in the lung, and associations between ADRB2 polymorphisms and intermediate phenotypes of asthma have been reported. Four missense polymorphisms (Arg16Gly, Gln27Glu, Val34Met, and Thr164Ile) and one polymorphism in the 5' leader cistron of the ADRB2 messenger RNA has been identified. In vitro studies have shown that these missense polymorphisms can affect ADRB2 function. To examine possible associations of ADRB2 polymorphisms with asthma susceptibility, we performed transmission disequilibrium tests (TDT) of 137 Japanese families identified through children with atopic asthma. We did not find associations between any alleles of the ADRB2 polymorphisms and asthma by TDT (p > 0.1). We also performed a meta-analysis of data from all available studies. The random-effects model showed no significant odds ratio for the Arg16Gln (odds ratio = 1.05, p = 0.53) or Gln27Glu (odds ratio = 1.12, p = 0.22) polymorphism. Our data indicate that ADRB2 does not contribute substantially to susceptibility to asthma, but it is possible that these polymorphisms influence disease activity and drug responses in individuals with asthma.Keywords
This publication has 12 references indexed in Scilit:
- Association between β2-adrenoceptor polymorphisms and asthma diagnosis among Mexican adultsJournal of Allergy and Clinical Immunology, 2003
- Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common diseaseNature Genetics, 2003
- Control of eukaryotic protein synthesis by upstream open reading frames in the 5′-untranslated region of an mRNABiochemical Journal, 2002
- Association between TNFA Polymorphism and the Development of Asthma in the Japanese PopulationAmerican Journal of Respiratory and Critical Care Medicine, 2002
- Association of β2-adrenoreceptor polymorphisms with nocturnal cough among atopic subjects but not with atopy and nonspecific bronchial hyperresponsivenessJournal of Allergy and Clinical Immunology, 2002
- beta2 adrenoceptor promoter polymorphisms: extended haplotypes and functional effects in peripheral blood mononuclear cellsThorax, 2002
- Association of β2‐adrenergic receptor polymorphisms with severe asthmaClinical and Experimental Allergy, 2000
- Association between β2-adrenoceptor polymorphism and susceptibility to bronchodilator desensitisation in moderately severe stable asthmaticsThe Lancet, 1997
- A genome-wide search for asthma susceptibility loci in ethnically diverse populationsNature Genetics, 1997
- An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteinsNature, 1987