Structural polymorphism of the DC1 light chains from DR1-, DR2-, and DRw6-positive cell lines

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Abstract
The heavy and light chain subunits of the DC1 antigen from several cell lines expressing different DR specificities were compared by two-dimensional (2-D) gel electrophoresis. The DC1 light chains from cell lines typed as DR1, DR2, or DRw6 differed in their isoelectric points. No difference in charge was observed for the DC 1 heavy chain from the three cell lines. The DC1 light chains from different DRw6-positive cell lines were also found to be structurally polymorphic. The DRw6 cell lines examined did not all express the same DR-like light chains, indicating that the DRw6 specificity is biochemically complex, which is in agreement with the serologic studies of others.