Augmentation of cysteamine-induced ulceration of rat duodenum by systemically administered ?-aminobutyric acid (GABA)
- 1 August 1989
- journal article
- research article
- Published by Springer Nature in Digestive Diseases and Sciences
- Vol. 34 (8) , 1211-1216
- https://doi.org/10.1007/bf01537269
Abstract
Subcutaneous administration of a single dose of γ-aminobutyric acid (GABA, 10 mg/100 g) in conjunction with a pretreatment dose of aminooxyacetic acid (AOAA 2.5 mg/100 g subcutaneously) to prevent the degradation of GABA, significantly augmented the incidence and intensity of cysteamine HCl-induced duodenal ulceration in rats. This effect of GABA could be reduced by the GABA receptor antagonist, bicuculline (30 Μg/100 g subcutaneously). These results suggest peripheral GABA receptors can modulate cysteamine HCl-induced duodenal ulcer.This publication has 26 references indexed in Scilit:
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